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Drug Coating


Drug Coating

Drug coating is the new pelletization range that builds on the proven Umang technology and its operational benefits. Similar design of twin screw loss in weight feeder, rotating plate and spray gun for liquid ensures that process and validation wise there is no difference to the layering process from a laboratory scale to a production scale. This unique design of twin screw feeder, plate and spray nozzle makes the not only a perfect drug layering machine but also an ideal machine suited for fast pelletization.

The outstanding feature of the Drug coating range is the integrated and CIP optimized design. Connections, cabling and supplies are completely integrated, covered and sealed so the outside of the machine is smooth and very easy to clean. The innovative discharge valve design and optimized seals inside the bowl allow for CIP. As a result of this the our Drug coating is highly flexible, quick product changeover increases productivity and cost effectiveness.

The drug coating capacity ranges from 500 gms to 120 Kgs./batch featuring through the wall design and movable head, allowing operation with platform and dust-free discharging via a linked mill directly into an IBC. The drug coating can be stand-alone or linked to a fluid bed wurster coating system to form an integrated system.


Standard Features for Fluid Bed Layering :

  •  Twin screw feeder configuration.
  •  CIP entry from top cover
  •  Perfect cGMP-design: smooth covering, no external tubing and piping allowing easy cleaning
  •  Completely integrated full opening side discharge: perfect discharge of difficult products
  •  Through the wall installation: minimum space required in GMP area
  •  User-friendly operator-machine interaction via graphical operator panel 12" Industrial PC software with PROCESS + range of software which helps interlinking all plant equipments to a single system.
  •  Flexibility (processes and products) for wet granulation.

Standard Features for Fluid Bed Coating :

  •  Explosion proof design.
  •  Automatic cleaning (WIP/CIP) of entire system.
  •  21 CFR part 11 certified controls.
  •  ADVANCE PROCESS + for easy and automated granulation control
  •  Jacketed / insulated bowl
  •  Total containment through up- and downstream split valves and flexible isolation systems.
  •  Integration with mill and/or fluid bed possible: perfect closed link for dust-free operation
  •  Video monitoring of the process
  •  Product feeding both by gravity or vacuum loading system directly from the containers
  •  Validation documentation and assistance based on GAMP

Management

RAJKUMAR BUDHRAJA

Mr. Rajkumar Budhraja is the Managing Director & Chief Executive Officer founder of Umang Group of Companies. He is endowed with a brilliant financial acumen master in strategic planning and corporate affairs. Besides Umang Pharmatech Pvt. Ltd. India, he is also a Board member of Caleva Process Solutions Ltd., UK. He has 35 years of experience in the pharmaceuticals, specialty chemicals, foods, oil & gas and allied process industry sectors.

UMANG BUDHRAJA

Mr. Umang R. Budhraja, Chief Operating Officer, son of Mr. Rajkumar Budhraja, is a man who always sees life in a positive light and believes in confronting challenges head-on. At a young age he has made an indelible imprint in running a corporate conglomerate and can be a fountain of inspiration to any aspiring businessman. He is also the board member of other corporate companies in USA, UK.

NIDHI BUDHRAJA

Dr. Nidhi U. Budhraja graduated from the University of Mumbai [ India ] in Medicines.She joined the Group where she led the company's Research, Development & Innovation function. Dr. Budhraja is a Chartered Researcher and member of several professional bodies besides the primary responsibilities of UMANG. She is also among the core members of the strategic team for research and development in UPPL.

PAYAL BUDHRAJA

Ms. Payal Budhraja, daughter of Mr. Rajkumar Budhraja graduated with a Masters of Pharmacy degree with Honors from the University of Nottingham. She is a Registered Pharmacist under the General Pharmaceutical Council in United Kingdom. A key member of the growing team, Payal is currently heading the Research and Development department at the company. She is self-motivated and driven to take the business forward and continue to innovatein the field of encapsulation and various new techniques on it.

Innovations

  Immediate Release Pellets
"Umang offers technology of state of the art equipments and complete range of Products for "Pharmaceutical pellets" and "Mouth dissolving films", UMANG is the innovator and industry standard for complete Pellet processing solutions, and offers a range of solutions for IMMEDIATE RELEASE of pellets / tablets by Fluid bed wurster coating or fluid bed processor or by extrusion and spheronization or drug layering technology for immediate release solid dose applications. Our machines and technology produce attractive and stable on even the most challenging formulations."
  Controlled Release Pellets
"Controlled release technology, also known as sustained-release, sustained-action, extended-release, Controlled-release or Controlledd-release, Time-release, modified release, or continuous-release, is a mechanism used in pill tablets or capsules to dissolve slowly and release a drug over time. The advantages of sustained-release tablets or capsules are that they can often be taken less frequently than instant-release formulations of the same drug, and that they keep steadier levels of the drug in the bloodstream."
  Sustained Release Pellets
"Sustained release technology, also known as sustained-action, extended-release, Controlled-release or Controlledd-release, Time-release, modified release, or continuous-release, is a mechanism used in pill tablets or capsules to dissolve slowly and release a drug over time. The advantages of sustained-release tablets or capsules are that they can often be taken less frequently than instant-release formulations of the same drug, and that they keep steadier levels of the drug in the bloodstream."
  Delayed Release Pellets
"Pellet (or bead) technology allows a variety of different drug delivery profiles to be achieved by coating drug and excipient with various polymers. The drug cores are generally spheroidal in shape and have a diameter in the range of 300-1,700 μm. Two types of process are used to generate the spheroidal pblog. The first of these processes, which allows potencies up to 90%, utilizes extrusion and spher’oidisation to form a drug core with a polymer coat."
  Enteric Coating Pellets
"An enteric coating is a barrier applied to oral medication that controls the location in the digestive system, where it is absorbed. Enteric refers to the small intestine, therefore enteric coatings prevent release of medication before it reaches the small intestine."
  Hot Melt Extrusion
"Incorporation of a drug in a polymer matrix is often used to sustain drug release. To producethese sustained-release matrices, hot-meltextrusion (HME) is becoming a widely-used technology in the pharmaceutical industry. Its major advantage over conventional techniques for manufacturing of sustained-release matrices (e.g. compression) is the continuity of the hot stage extrusion technique as the different process steps (mixing, melting, homogenizing and shaping) are carried out on a single machine. "
  Oral Dissolving Films
"Fast oral dissolving films have become popular as a new delivery system because they are easy to administer and sudden-onset of drug action is possible as the films are taken through the sublingual route. Since the sublingual mucosa is relatively permeable because of thin membrane and is highly perfused, rapid drug absorption and instant bio-availability is possible and this leads to quick-onset of drug action. "
  Drug Layering
"Centrifugal processing is single unit operation. The process involves the deposition of successive layers of an active compound onto nonpareil seeds resulting in the formation of uniform sized pellets. The operation is carried out using a plain rotating plate. During processing the starter seeds are wetted with a moistening liquid while rotating on the base plate. "
  Liquid Filled Beads
"Our line of seamless capsule beads, developed and manufactured in Mumbai. India has a team of experts will provide you with tailor-made solutions from formulation through development and launch of your seamless liquid filled capsule products. We maintain leading edge capabilities with the most up-to-date manufacturing and quality control for seamless capsule technology. "
  Homogenizer
"Laboratory size Homogenizer, Capacity 200gm – 1000gm., Glass Construction, Heavy 18,000 RPM, Forward & Reward mixing arrangement to have homogeneous mass. "
  Continuous Mixer
"Laboratory size Homogenizer, Capacity 200gm – 1000gm., Glass Construction, Heavy 18,000 RPM, Forward & Reward mixing arrangement to have homogeneous mass. "
  10 and 12 Bar Fluid Bed
"Design and construction for total containment requires that the entire system is sealed to the environment. This applies during the entire processing cycle including the feed and discharge stages. UPPL provides traditional 2-bar vented systems as well as full 10-bar explosion containment systems. These special 12-bar containment systems insure that no material must escape into the environment in the rare instance of an explosion up to 10-Bar pressures."
  Micro Pellets
"UPPL micro pelleting expertise has been developed through matching the unique requirements of our client base during our production of several hundred extrusion systems provided for pharmaceutical and agricultural applications. It is typical that the smaller the extrudates required below 500 microns are the more difficult it is to maintain low sheer, high capacity, and continued extruder operation without blinding. UPPL has overcome these difficulties with our unique Micro Pellet die designs available for our Cone, Radial and Die Roller extrusion systems."
  Film Shapes
"We can formulate shapes using a custom flavor or a proprietary flavor supplied by the customer. We also have a range of flavors available as standard products."

Clients